Detection of endogenous PSD-95, α-actinin and other proteins and their interactions in live cells by fluorescent peptides

The objective of this team will be to pioneer a novel imaging method to map brain connectivity on a molecular level. More specifically, the team will explore the dynamic interactions between synaptic proteins and binding partners, as well as identify when and where they occur. Most major synaptic proteins have been identified, but their precise localization and dynamics at various synapses is almost completely unknown.